Clinical efficacy of tirofiban combined with a Solitaire stent in treating acute ischemic stroke

医学 纸牌密码算法 替罗非班 改良兰金量表 溶栓 脑梗塞 支架 冲程(发动机) 闭塞 外科 脑血管造影 大脑中动脉 血管造影 内科学 缺血 心肌梗塞 缺血性中风 经皮冠状动脉介入治疗 机械工程 工程类
作者
Yang Zhang,Qingqing Zhang,Fengyu Cong,Lei Wang,Guanqun Zhang,Pei-Wei Cao,Guofang Chen,Xiangsheng Fu
出处
期刊:Brazilian Journal of Medical and Biological Research [Associação Brasileira de Divulgação Científica]
卷期号:52 (10) 被引量:16
标识
DOI:10.1590/1414-431x20198396
摘要

This study explores the safety and effect of acute cerebral infarction treatment by microcatheter injection of tirofiban combined with a Solitaire AB stent and/or stent implantation. Emergency cerebral angiograms showing the responsible vascular occlusion of 120 acute cerebral infarction patients who underwent emergency endovascular thrombectomy were included in the study. These patients were randomly divided into two groups using the random number table method: treatment group (n=60) that received thrombectomy (with cerebral artery stents) combined with intracerebral injection of tirofiban and control group (n=60) that only received thrombectomy (with cerebral artery stents alone). The baseline data, cerebral angiography before and after surgery, hospitalization, and follow-up results of patients in these two groups were compared. Furthermore, the incidence of major adverse cerebrovascular events of these two groups was compared (90-day modified Rankin scale, a score of 0–2 indicates a good prognosis). The difference between baseline clinical data and brain angiography between these two groups was not statistically significant. Patients in the treatment group had a higher prevalence of thrombolysis in cerebral infarction grade 2b/3 than patients in the control group (88.3% (53/60) vs 66.7% (40/60), P=0.036). Moreover, the National Institutes of Health Stroke Scale scores 7 days after surgery and the 90-day prognosis were all better for the patients who received tirofiban (P=0.048 and P=0.024). Mechanical thrombectomy with Solitaire AB stents in combination with the injection of tirofiban through a microcatheter appears to be safe and effective for the endovascular treatment of acute ischemic stroke.
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