Effect of Oral Moxifloxacin vs Intravenous Ertapenem Plus Oral Levofloxacin for Treatment of Uncomplicated Acute Appendicitis

医学 莫西沙星 左氧氟沙星 随机对照试验 抗生素 养生 厄他培南 临床终点 甲硝唑 外科 内科学 美罗培南 抗生素耐药性 生物 微生物学
作者
Suvi Sippola,Jussi Haijanen,Juha Grönroos,Tero Rautio,Pia Nordström,Tuomo Rantanen,Tarja Pinta,Imre Ilves,Anne Mattila,Jukka Rintala,Eliisa Löyttyniemi,Saija Hurme,Ville Tammilehto,Harri Marttila,Sanna Meriläinen,Johanna Laukkarinen,Eeva-Liisa Sävelä,Heini Savolainen,Tomi Sippola,Markku Aarnio,Hannu Paajanen,Paulina Salminen
出处
期刊:JAMA [American Medical Association]
卷期号:325 (4): 353-353 被引量:53
标识
DOI:10.1001/jama.2020.23525
摘要

Importance

Antibiotics are an effective and safe alternative to appendectomy for managing uncomplicated acute appendicitis, but the optimal antibiotic regimen is not known.

Objective

To compare oral antibiotics with combined intravenous followed by oral antibiotics in the management of computed tomography–confirmed uncomplicated acute appendicitis.

Design, Setting, and Participants

The Appendicitis Acuta (APPAC) II multicenter, open-label, noninferiority randomized clinical trial was conducted from April 2017 until November 2018 in 9 Finnish hospitals. A total of 599 patients aged 18 to 60 years with computed tomography–confirmed uncomplicated acute appendicitis were enrolled in the trial. The last date of follow-up was November 29, 2019.

Interventions

Patients randomized to receive oral monotherapy (n = 295) received oral moxifloxacin (400 mg/d) for 7 days. Patients randomized to receive intravenous antibiotics followed by oral antibiotics (n = 288) received intravenous ertapenem (1 g/d) for 2 days followed by oral levofloxacin (500 mg/d) and metronidazole (500 mg 3 times/d) for 5 days.

Main Outcomes and Measures

The primary end point was treatment success (≥65%) for both groups, defined as discharge from hospital without surgery and no recurrent appendicitis during 1-year follow-up, and to determine whether oral antibiotics alone were noninferior to intravenous and oral antibiotics, with a margin of 6% for difference.

Results

Among 599 patients who were randomized (mean [SD] age, 36 [12] years; 263 [44%] women), 581 (99.7%) were available for the 1-year follow-up. The treatment success rate at 1 year was 70.2% (1-sided 95% CI, 65.8% to ∞) for patients treated with oral antibiotics and 73.8% (1-sided 95% CI, 69.5% to ∞) for patients treated with intravenous followed by oral antibiotics. The difference was −3.6% ([1-sided 95% CI, −9.7% to ∞];P = .26 for noninferiority), with the confidence limit exceeding the noninferiority margin.

Conclusion and Relevance

Among adults with uncomplicated acute appendicitis, treatment with 7 days of oral moxifloxacin compared with 2 days of intravenous ertapenem followed by 5 days of levofloxacin and metronidazole resulted in treatment success rates greater than 65% in both groups, but failed to demonstrate noninferiority for treatment success of oral antibiotics compared with intravenous followed by oral antibiotics.

Trial Registration

ClinicalTrials.gov Identifier:NCT03236961; EudraCT Identifier:2015-003633-10
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