Immunological regulation of CD70/CD27 pathway and the expression of CD70 in tumor

CD70/CD27 pathway plays an important role in human immune regulation. The role of CD70/CD27 pathway in immune regulation is mainly to promote the activation and proliferation of T cells, induce the differentiation and formation of effector T cells and memory T cells, and interfere with regulatory T cells. In addition, the high level of CD70 expression in some tumor cells provides a new way for tumor immunotherapy. Key words: Immunity, cellular; Neoplasms; CD70/CD27 pathway