Analysis of hematopoietic system damage in 210 patients with brucellosis

Objective The correlation between blood system damage and splenomegaly in brucellosis patients and their effects on liver function were analyzed. Methods Data were retrospectively collected in patients with blood system damage diagnosed of brucellosis from 2005 to 2016 at the Department of Infectious Disease of Harbin Medical University First Affiliated Hospital. At the same time, test results of the selected patients liver function, ferritin, D-dimer and abdominal ultrasonography were collected. According to splenomegaly or not, patients were divided into splenomegaly and no-splenomegaly, and any difference in hematopoietic damage caused by splenomegaly or not was analyzed. Results Of the 210 patients (101 cases of splenomegaly, 109 cases without splenomegaly), 170 were male (80.95%), 40 were women (19.05%), and age was (39.65 ± 10.79) years. The patients with abnormal blood system were 103 cases (49.05%); in splenomegaly group there were 58 cases of blood system damage; in no-splenomegaly group there were 45 cases of blood system damage, and there was a statistically significant difference between the two groups (χ2= 5.465, P 0.05). Ferritin increased in 26 cases (12.38%). D-dimer increased in 22 cases (10.48%). There were 93 patients with splenomegaly and transaminase elevation, and 58 patients with non-splenomegaly and transaminase elevation. There were significant differences between the two groups (χ2= 39.204, P < 0.05). Conclusion Brucellosis can cause blood system damage, probably caused by splenomegaly; and patients with brucellosis are often accompanied by elevated transaminases. Key words: Brucellosis; Hematopoietic system damage; Splenomegaly; Aminotransferases elevated