毛乳头
毛囊
绒毛
十二指肠大乳头
雄激素
雄激素受体
生物
二氢睾酮
脱发
内分泌学
男性型秃发
头发周期
睾酮(贴片)
内科学
毛发病
细胞生物学
皮肤病科
医学
解剖
遗传学
激素
癌症
头皮
前列腺癌
标识
DOI:10.3760/cma.j.issn.1673-4173.2010.01.016
摘要
Androgenetie alopecia(AGA),the most common baldness,is a polygenic hereditary disease of unknown origin.It has been revealed that the pathogenesis of AGA is associated with androgen (especially dihydrotestosterone) and with mental factors.Dermal papilla cells (DPC),which originate from fibroblasts,are mesenehyme cells of hair papilla.DPC express androgen receptors,secrete a variety of cell factors,induce hair follicle regeneration and play an important role in hair follicle cycle.In addition,DPC are concerned with the metabolism of androgen that can stimulate DPC from sensitive hair follicles to secrete soluble cell factors and result in baldness.Therofore,DPC have a close relationship with AGA.
Key words:
Dermal papilla cells; Alopecia; Androgens
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