Clinical utility value of urinary aldosterone detection by tandem mass spectrometry in primary hyperaldosteronism screening

醛固酮增多症 医学 内科学 原发性醛固酮增多症 血浆肾素活性 醛固酮 接收机工作特性 泌尿系统 内分泌学 尿 胃肠病学 泌尿科 肾素-血管紧张素系统 血压
作者
Wenjun Ma,Jin‐Song Bian,Ying Lou,Xu Yang,Huimin Zhang,Xianliang Zhou,Lei Song,Jun Cai,Beibei Zhao,Ergang Jiang,Weixia Liu,Yating Cheng
出处
期刊:Chinese Journal of Laboratory Medicine [Chinese Medical Association]
卷期号:43 (03): 261-266 被引量:1
标识
DOI:10.3760/cma.j.issn.1009-9158.2020.03.013
摘要

Objective To explore the clinical utility of liquid chromatography tandem mass spectrometry forprimary aldosteronism screening. Methods From January to October 2019, 413 inpatients diagnosed hypertension from Fuwai Hospital of Chinese Academy of Medical Sciences were enrolled, including 60 Primary aldosteronism(PA)patients and 353 primary hypertension patients. The plasma aldosterone concentration (PAC) and renin concentration (DRC) were measured after 2 h of standing. The 24 h urine samples were collected for measurement of aldosterone using LC-MS/MS. The performance of urine aldosterone and urine aldosterone/renin ratio (UADRR) in PA screening was evaluated by ROC, and compared with PAC/DRC ratio (ADRR). Meanwhile, the efficiency of urine aldosterone in elderly patients or patients with low blood potassium or 24 h urine sodium over 200 mmol was investigated. Results Area under the curve (AUC)of urine aldosterone was 0.725 (95%CI 0.679-0.767), and the best cut-off was 7.13 μg/24 h, which was lower than AUC of ADRR (0.958, 95%CI 0.934-0.975). The AUC of UADRR was 0.947 (95%CI 0.920-0.966), the best cut-off was 1.11 (μg/24 h)/(μIU/ml), the sensitivity and specificity were 91.7% and 89.0%, respectively. There is no significant differences found with ADRR. In patients with 24 h urine sodium over 200 mmol, AUC of aldosterone was 0.834 (95%CI 0.730-0.910) and the best cut-off was 9.31 μg/24 h. The sensitivity and specificity were 90.9% and 68.7%, respectively. For the elderly patients over 60 years old, the AUC of urinary aldosterone was 0.860 (95%CI 0.770-0.925), and the best cut-off was 6.91 μg/24 h. The sensitivity and specificity were 84.6% and 81.3%, respectively. When admission blood potassium was less than 3.50 mmol/L, AUC of urinary aldosterone was 0.822 (95%CI 0.684-0.917), and the best cut-off was 10.63 μg/24 h. The sensitivity and specificity were 85.7% and 66.7%, respectively. Conclusion The detection of aldosterone in urine by LC-MS/MS can provide clinical information for PA screening, and the screening performance is better in patients with 24-hour urine sodium over 200 mmol, elderly patients or patients with low blood potassium. If combined with renin, screening efficiency was the same as that in ADRR. Key words: Hyperaldosteronism; Aldosterone; Urinalysis; Tandem mass spectrometry; Chromatography, liquid
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