The preoperative serum CA125 can predict the lymph node metastasis in endometrioid-type endometrial cancer

医学 子宫内膜癌 淋巴结转移 肿瘤科 内科学 转移 淋巴结 癌症
作者
Mehmet Ünsal,Günsu Kimyon Cömert,Alper Karalök,Derman Başaran,Osman Türkmen,Gökhan Boyraz,Tolga Taşçı,Sevgi Koç,Nurettin Boran,Gökhan Tulunay,Taner Turan
出处
期刊:Ginekologia Polska [Via Medica]
卷期号:89 (11): 599-606 被引量:16
标识
DOI:10.5603/gp.a2018.0103
摘要

To evaluate the predictive value of preoperative CA125 in extra-uterine disease and its association with poor prognostic factors in endometrioid-type endometrial cancer (EC).A total of 423 patients with pathologically proven endometrioid-type EC were included in the study. The association between preoperative CA125 level and surgical-pathological factors was evaluated. The conventional cut-off value was defined as 35 IU/mL.A high CA125 level ( > 35 IU/mL) was significantly associated with all of the studied poor prognostic factors, except grade. The risk of lymph node metastasis (LNM) increased from 15.9% to 45.7% when CA125 level was > 35 IU/mL (p < 0.05). The optimal cut-off value for the prediction of LNM in patients aged > 50 years was determined to be 16 IU/mL (sensitivity, specificity, positive predictive value, and negative predictive value were 71%, 60%, 35%, and 87%, respectively.) Conclusions: Preoperative CA125 level was significantly related with the extent of the disease and LNM. The age-dependent cut-off level of CA125 can improve the prediction of LNM in endometrioid-type EC. For older patients, CA125 level of > 16 IU/ml could be used to predict LNM. However, further studies are needed to evaluate the appropriate cut-off level of CA125 for younger patients.
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