医学
磷脂酰肌醇
癌症
PI3K/AKT/mTOR通路
激酶
细胞生长
淋巴瘤
信号转导
蛋白激酶B
癌症研究
内科学
免疫学
细胞生物学
生物化学
生物
作者
Marcus D. Goncalves,Benjamin D. Hopkins,Lewis C. Cantley
标识
DOI:10.1056/nejmra1704560
摘要
Phosphatidylinositol 3-kinase (PI3K) is involved in multiple cell processes, including insulin signaling, cell growth, immunity, and brain development. It is activated in a wide variety of cancers and is being targeted as a treatment, with notable success in lymphoma.
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