材料科学
胍
涂层
衍生工具(金融)
抗菌活性
化学工程
细菌
组合化学
化学
纳米技术
有机化学
生物
遗传学
金融经济学
工程类
经济
作者
Huan Yu,Lin Liu,Huawei Yang,Rongtao Zhou,Chaoyue Che,Xue Li,Chunsheng Li,Shifang Luan,Jinghua Yin,Hengchong Shi
标识
DOI:10.1021/acsami.8b13868
摘要
Antibacterial coatings have been considered as an effective method for preventing the implant-associated infections caused by the bacterial colonization. In this study, we report a water-insoluble polyelectrolyte–surfactant complex, poly(hexamethylene biguanide) hydrochloride–sodium stearate (PHMB–SS) that can be facilely coated onto the surfaces of biomedical catheter and kill the bacteria by releasing the PHMB and prevent the generation of the biofilm. The PHMB–SS-coated surfaces showed better bactericidal activity toward Staphylococcus aureus and Escherichia coli. The PHMB–SS-coated catheters could not only relatively prevent the bacterial colonization in vitro but also in an implant-associated bacterial infection animal model in vivo. Moreover, no significant cytotoxicity and host response were observed in vitro and in vivo, indicating the high biocompatibility of the coating. The water-insoluble antibacterial coating reported in this work represents a novel approach to build a simple and effective coating for the prevention of device-associated infections.
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