牙龈卟啉单胞菌
骨骼肌
肌萎缩
咬肌
内科学
内分泌学
心肌细胞
医学
纤维化
牙周炎
脂多糖
解剖
作者
Naoya Kawamura,Yoshiki Ohnuki,Ichiro Matsuo,Kenji Suyama,Misao Ishikawa,Yasumasa Mototani,Kouichi Shiozawa,Aiko Ito,Yuka Yagisawa,Yoshio Hayakawa,Megumi Nariyama,Daisuke Umeki,Yuko Ujiie,Kazuhiro Gomi,Satoshi Okumura
标识
DOI:10.1007/s12576-019-00670-z
摘要
Periodontitis, which is caused by various oral organisms, predominantly affects adults, and is one of the main causes of tooth loss, as well as leading to progression of numerous systemic diseases. However, its relationship to sarcopenia (aging-associated degenerative loss of skeletal muscle mass and function) remains unclear. The aim of this study was to investigate the effects of Porphyromonas gingivalis lipopolysaccharide (PG-LPS) on skeletal muscle in mice, and to establish the underlying mechanisms. Mice (C57BL/6) were injected with PG-LPS (0.8 mg/kg/day) for 4 weeks. This treatment significantly decreased the weight of fast-twitch skeletal muscles (masseter and tibialis anterior muscles), but not that of slow-twitch skeletal muscle (soleus muscle). The area of fibrosis was significantly increased in masseter muscle, but remained unchanged in the other two muscles. The number of apoptotic myocytes was significantly increased (approximately eightfold) in masseter muscle. These data suggest that persistent subclinical exposure to PG-LPS might reduce the size of fast-twitch skeletal muscle, but not slow-twitch skeletal muscle. Masseter muscle appears to be especially susceptible to the adverse effects of PG-LPS, because muscle remodeling (muscle fibrosis and myocyte apoptosis) was induced solely in masseter muscle. Thus, periodontitis might be one of the major causes of oral sarcopenia.
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