生物利用度
壳聚糖
口服
药理学
化学
PLGA公司
铵
药物输送
药品
微球
剂型
药代动力学
盐(化学)
色谱法
医学
生物化学
化学工程
工程类
物理化学
有机化学
体外
作者
Shih‐Ming He,Wenliang Fu,Minji Zou,Weiwei Xing,Zhongcheng Liu,Donggang Xu
标识
DOI:10.1080/1061186x.2019.1605520
摘要
The aim of this study was to realize the oral delivery of SAK-HV protein and improve its oral bioavailability based on chitosan quaternary ammonium salt-PLGA microsphere. The results showed that the SAK-HV-loaded microsphere can overcome the multiple obstacles for oral adsorption and adhere effectively to the jejunal segment of a rat. The pharmacokinetic analysis of the oral drug-loaded microspheres in rats showed that the blood drug concentration of SAK-HV reached the peak value at 4 h after oral administration, and the relative oral bioavailability of SAK-HV was 3.4%. Additionally, after oral administration to the mice, a higher level of antibody against SAK-HV was produced on day 21 compared with that in the control and injection groups, and the antibody titre was 7.2 times that of the tail vein group. This work suggests that the microsphere of the chitosan quaternary ammonium salt-PLGA may be a promising drug delivery system for the oral administration of SAK-HV protein.
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