槲皮素
类黄酮
细胞毒性T细胞
细胞培养
化学
生物活性
细胞生长
生物化学
细胞毒性
生长抑制
生物
体外
抗氧化剂
遗传学
作者
Gardênia Carmen Gadelha Militão,Maria Rose Jane R. Albuquerque,Otília Deusdênia Loiola Pessoa,Cláudia Pessoa,Maria Elisabete Amaral de Moraes,Milton Ozório Moraes,Letícia V. Costa‐Lotufo
出处
期刊:PubMed
日期:2004-12-01
卷期号:59 (12): 965-6
被引量:13
摘要
The present study evaluated the cytotoxic activity of nepetin and quercetin-3-O-glucoside, compounds isolated from the aerial parts of Eupatorium ballotaefolium. The antimitotic activity was determined as the ability to inhibit sea urchin eggs development and five tumor cells lines growth. Moreover, the activities of these compounds were compared to quercetin in the same models. Nepetin inhibited the proliferation of the five tumor cell lines, once quercetin-3-O-glucoside did not present any activity even at the highest tested concentration and quercetin only inhibited proliferation of the B16 cell line. On the sea urchin assay, nepetin and quercetin induced a dose-dependent inhibition on egg development, while quercetin-3-O-glucoside did not modify normalegg cleavage, even at the highest tested concentration (100 microg/ml).
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