引用
社会化媒体
偶像
计算机科学
情报检索
图书馆学
万维网
程序设计语言
作者
Daniel L. Flynn,Thomas R. Belliotti,Amal M. Boctor,David T. Connor,Catherine R. Kostlan,Donald E. Nies,Daniel F. Ortwine,Denis J. Schrier,J. C. Sircar
摘要
A series of styrylpyrazoles, styrylisoxazoles, and styrylisothiazoles were prepared and found to be dual inhibitors of 5-lipoxygenase and cyclooxygenase in rat basophilic leukemia cells. Compounds from this series also were found to inhibit the in vivo production of LTB4 when dosed orally in rats. Among these compounds, di-tert-butylphenols 19 and 33 exhibit oral activity in various models of inflammation and, most importantly, are devoid of ulcerogenic potential.
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