染色质
细胞生物学
组蛋白修饰酶
组蛋白
抄写(语言学)
生物
真核转录
细胞
伴侣(临床)
转录因子
计算生物学
核小体
DNA
遗传学
发起人
基因表达
基因
医学
语言学
哲学
病理
作者
Katerina V. Gurova,Han-Wen Chang,Maria E. Valieva,Poorva Sandlesh,Vasily M. Studitsky
标识
DOI:10.1016/j.bbagrm.2018.07.008
摘要
FAcilitates Chromatin Transcription (FACT) has been considered essential for transcription through chromatin mostly based on cell-free experiments. However, FACT inactivation in cells does not cause a significant reduction in transcription. Moreover, not all mammalian cells require FACT for viability. Here we synthesize information from different organisms to reveal the core function(s) of FACT and propose a model that reconciles the cell-free and cell-based observations. We describe FACT structure and nucleosomal interactions, and their roles in FACT-dependent transcription, replication and repair. The variable requirements for FACT among different tumor and non-tumor cells suggest that various FACT-dependent processes have significantly different levels of relative importance in different eukaryotic cells. We propose that the stability of chromatin, which might vary among different cell types, dictates these diverse requirements for FACT to support cell viability. Since tumor cells are among the most sensitive to FACT inhibition, this vulnerability could be exploited for cancer treatment.
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