猫杯状病毒
猫
组织病理学
毒力
病毒学
生物
系统发育树
免疫组织化学
杯状病毒科
病毒
杯状病毒
病理
医学
基因
病毒性疾病
免疫学
遗传学
内科学
作者
Francesca Caringella,Gabriella Elia,Nicola Decaro,Vito Martella,Gianvito Lanave,Katia Varello,Cristiana Catella,Georgia Diakoudi,Grazia Carelli,Maria Loredana Colaianni,Stefano Bò,Canio Buonavoglia
标识
DOI:10.1016/j.rvsc.2019.02.008
摘要
Feline calicivirus (FCV) is a contagious viral pathogen that usually causes a mild, self-limiting respiratory disease. More recently, highly virulent FCV strains have emerged and have been associated with severe systemic infection, referred to as virulent systemic disease (VSD). The objective of this study is to report VSD cases in Italian cats along with the molecular characterization of two detected FCV strains. Three client-owned cats showed clinical signs resembling to those described for VSD cases. The cats were subjected to molecular investigations for detection of FCV and other feline pathogens. Histopathology and immunohistochemistry were performed on internal organs of one cat; molecular characterization of two detected FCV strains was obtained through sequence and phylogenetic analyses. Putative VS-FCV strains were detected in all three cats, which were co-infected with feline panleukopenia virus. The cat submitted to histopathology and immunohistochemistry displayed severe histological changes and FCV antigens in internal organs. Two Italian FCV strains, for which amplification of ORF2 was successful, were strictly related and formed a unique phylogenetic cluster. These viruses did not show consistent changes in the amino acid sequences with respect to reference VS-FCVs. The results of our study confirm that VS-FCV strains are circulating in Italy and that VSD diagnosis is complicated since both genetic and clinical markers have not been identified so far.
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