电化学发光
四苯乙烯
化学
分子内力
聚集诱导发射
发光
检出限
荧光
生物传感器
阴极
分子
立体化学
光电子学
色谱法
物理化学
光学
有机化学
材料科学
生物化学
物理
作者
Minghui Jiang,Sheng-Kai Li,Xia Zhong,Wenbin Liang,Yaqin Chai,Ying Zhuo,Ruo Yuan
标识
DOI:10.1021/acs.analchem.8b05949
摘要
Apart from the reported energy transfer mechanism of aggregation-induced electrochemiluminescence (AI-ECL) enhancement, a new strategy named restriction of intramolecular motions-driven ECL (RIM-ECL) enhancement is first proposed based on the phenomenon of a very strong electrochemiluminescence observed on the hexagonal tetraphenylethylene microcrystals (TPE MCs) in aqueous solution. Compared to TPE in molecule-isolation state with faint ECL, TPE in aggregate state (TPE MCs) showed a significantly enhanced ECL that was due to the restriction of intramolecular motions (RIM). Inspired by the unique luminescence characteristic of TPE MCs, we integrated the novel ECL emitter of TPE MCs and target-activated bipedal DNA walker together to fabricate a sensitive “off-on” ECL biosensor for Mucin 1 (MUC1) assay, which exhibited desirable linear response for a concentration scope from 1 fg/mL to 1 ng/mL with a low detection limit of 0.29 fg/mL. The RIM enhanced ECL demonstrated by the TPE MCs provides a new chapter in the exploration of aggregated organic emitters for further applications.
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