Highly efficient copper-catalyzed direct C–H amidation of quinoxalin-2(1H)-ones with amidates under microwave irradiation

A novel and convenient protocol for the construction of 3-amidated quinoxalin-2(1H)-ones was developed via copper-catalyzed direct oxidative amidation of quinoxalin-2(1H)-ones with amidates using K₂S₂O₈ as an oxidant, and under microwave irradiation.