锡克
医学
肾病
肾脏疾病
发病机制
免疫学
安慰剂
酪氨酸激酶
肾小球肾炎
肾
内科学
受体
内分泌学
病理
替代医学
糖尿病
作者
F. Tam WK,James A. Tumlin,Jonathan Barratt,B. Rovin H,Ivanov Sd,Candice Roufosse,H T Cook,Sandra Tong,Daniel B. Magilavy,Richard A. Lafayette
标识
DOI：10.1016/j.ekir.2019.05.431
摘要
IgA nephropathy (IgAN) is the most common primary glomerulonephritis worldwide, causing chronic kidney disease and end-stage renal disease. Pre-clinical data implicates SYK in the pathogenesis of IgAN (Kim MJ et al J Immunol 2012, McAdoo et al JASN 2014). We hypothesize that SYK inhibition with fostamatinib may represent a novel therapeutic opportunity.
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