Rapid high‐resolution T1 mapping using a highly accelerated radial steady‐state free‐precession technique

进动 稳态(化学) 高分辨率 稳态自由进动成像 分辨率(逻辑) 物理 核磁共振 材料科学 计算机科学 磁共振成像 医学 放射科 化学 地质学 凝聚态物理 遥感 人工智能 物理化学
作者
Zhitao Li,Ali Bilgin,Kevin M. Johnson,Jean‐Philippe Galons,Srinivasan Vedantham,Diego R. Martín,María I. Altbach
出处
期刊:Journal of Magnetic Resonance Imaging [Wiley]
卷期号:49 (1): 239-252 被引量:14
标识
DOI:10.1002/jmri.26170
摘要

T1 mapping is often used in some clinical protocols. Existing techniques are limited in slice coverage, and/or spatial-temporal resolution, or require long acquisitions. Here we present a multi-slice inversion-recovery (IR) radial steady-state free precession (radSSFP) pulse sequence combined with a principal component (PC) based reconstruction that overcomes these limitations.To develop a fast technique for multi-slice high-resolution T1 mapping.Technical efficacy study done prospectively.IR-radSSFP was tested in phantoms, five healthy volunteers, and four patients with abdominal lesions.IR-radSSFP was implemented at 3T.Computer simulations were performed to optimize the flip angle for T1 estimation; testing was done in phantoms using as reference an IR spin-echo pulse sequence. T1 mapping with IR-radSSFP was also assessed in vivo (brain and abdomen) and T1 values were compared with literature. T1 maps were also compared with a radial IR-FLASH technique.A two-tailed t-test was used to compare T1 values in phantoms. A repeatability study was carried out in vivo using Bland-Altman analysis.Simulations and phantom experiments showed that a flip angle of 20˚ was optimal for T1 mapping. When comparing single to multi-slice experiments in phantoms there were no significant differences between the means T1 values (P = 0.0475). In vivo results show that T1 maps with spatial resolution as high as 0.69 mm × 0.69 mm × 2.00 mm (brain) and 0.83 mm × 0.83 mm × 3.00 mm (abdomen) can be generated for 84 brain slices in 3 min and 10 abdominal slices in a breath-hold; T1 values were comparable to those reported in literature. The coefficients of variation from the repeatability study were 1.7% for brain and 2.5-2.7% in the abdomen.A multi-slice IR-radSSFP technique combined with a PC-based reconstruction was demonstrated for higher resolution T1 mapping. This technique is fast, motion-insensitive and yields repeatable T1 values comparable to those in literature.2 Technical Efficacy: Stage 1 J. Magn. Reson. Imaging 2019;49:239-252.
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