脂肪生成
产热
脂质代谢
生物
脂肪组织
脂肪细胞
小RNA
白色脂肪组织
细胞生物学
能源消耗
内分泌学
生物化学
基因
作者
Chen Chen,Qingming Cui,Xing Zhang,Xuan Luo,Yingying Liu,Jianbo Zuo,Yinglin Peng
标识
DOI:10.1016/j.cellsig.2018.07.012
摘要
Obesity is a widespread health problem that brings about various adipose tissue dysfunctions. The balance of energy storage and energy expenditure is critical for normal fat accumulation and lipid metabolism. Therefore, understanding the molecular basis of adipogenesis and thermogenesis is essential to maintain adipose development and lipid homeostasis. Increasing evidence demonstrated that lncRNAs (long non-coding RNAs), a class of non-protein coding RNAs of >200 nucleotides in length, are identified as key regulators in obesity-related biological processes through diverse regulatory mechanisms. In this review, we concentrate on recent and relevant studies on the roles of lncRNAs in regulation of white adipogenesis, brown adipocyte differentiation and lipid metabolism. In addition, the diagnostic and therapeutic potential of lncRNAs is highlighted, and that will make recommendations for the future application of lncRNAs in the treatment of obesity.
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