淋巴瘤
医学
浆母细胞性淋巴瘤
病理
套细胞淋巴瘤
T细胞淋巴瘤
淋巴母细胞淋巴瘤
免疫学
T细胞
免疫系统
标识
DOI:10.1080/17474086.2018.1506326
摘要
Introduction: Non-Hodgkin lymphomas of the oral and maxillofacial regions are uncommon malignancies. They usually have progressive course and dismal outcome.Areas covered: This review provides an update about the clinicopathologic, immunophenotypic, and molecular features of these lymphomas. Some relevant case reports are presented.Expert commentary: The lymphomas of the oral and maxillofacial regions involve the tongue, gingiva, hard palate, maxilla, mandible, Waldeyer’s ring, palatine, and lingual tonsils. They include diffuse large B-cell lymphoma (DLBCL), T-cell lymphoma, Burkitt lymphoma (BL), natural killer/T-cell lymphoma (NKTCL), marginal zone lymphoma, plasmablastic lymphoma (PBL), mantle cell lymphoma, and lymphoblastic lymphoma. They are more common in males than in females. They commonly present as mass lesions covered by an intact or ulcerated mucosa. Some lymphomas are associated with viral infections (Epstein–Barr virus or HIV) and specific genetic alterations. Each subtype has its specific clinicopathologic features and the most common subtypes include DLBCL, BL, NKTCL, and PBL. DLBCL is the most common oral lymphoma. BL is a rapidly proliferating mature B cell neoplasm almost always presenting in extranodal sites. Nasal-type NKTCL presents as a locally destructive, midfacial necrotizing lesion. PBL is a rare, highly aggressive disease that is commonly associated with immunodeficiency conditions.
科研通智能强力驱动
Strongly Powered by AbleSci AI