人工心脏
医学
脉动流
心脏病学
心脏移植
内科学
叶轮
移植
心室辅助装置
血流动力学
心力衰竭
机械工程
工程类
作者
William E. Cohn,Daniel Timms,O.H. Frazier
标识
DOI:10.1038/nrcardio.2015.79
摘要
A practical artificial heart has been sought for >50 years. An increasing number of people succumb to heart disease each year, but the number of hearts available for transplantation remains small. Early total artificial hearts mimicked the pumping action of the native heart. These positive-displacement pumps could provide adequate haemodynamic support and maintain the human circulation for short periods, but large size and limited durability adversely affected recipients' quality of life. Subsequent research into left ventricular assist devices led to the use of continuous-flow blood pumps with rotating impellers. Researchers have attempted to integrate this technology into modern total artificial hearts with moderate clinical success. The importance of pulsatile circulation remains unclear. Future research is, therefore, needed into positive-displacement and rotary total artificial hearts.
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