倍半萜
绝对构型
立体化学
化学
衍生工具(金融)
真菌
二维核磁共振波谱
青霉属
核磁共振波谱
海洋真菌
萜类
植物
生物
食品科学
金融经济学
经济
作者
Yue Zhou,Yunhai Li,Hao‐Bing Yu,Xiaoyu Liu,Xiaoling Lü,Binghua Jiao
标识
DOI:10.1080/10286020.2017.1385604
摘要
A new furanone derivative, butanolide A (1), and a new sesquiterpene, guignarderemophilane F (2), together with six known compounds, were isolated from the fungus Penicillium sp. S-1-18 derived from Antarctic marine. The new structures were determined by spectroscopic studies such as 1D- and 2D-NMR and MS analyses. The absolute configuration of 1 was determined by the modified Mosher’s method, while the absolute configuration of 2 was determined by calculated ECD spectroscopy. The isolated secondary metabolites were evaluated for their protein tyrosine phosphatase 1B (PTP1B) inhibitory activity. Compound 1 showed moderate inhibitory activity against PTP1B with IC50 value of 27.4 μM.
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