Features of dipeptidyl peptidase IV (DPP-IV) inhibitory peptides from dietary proteins

二肽基肽酶 水解物 胃抑制多肽 生物信息学 生物化学 化学 二肽基肽酶-4 抑制性突触后电位 食物蛋白 药理学 生物 激素 内分泌学 2型糖尿病 糖尿病 基因 胰高血糖素 水解
作者
Alice B. Nongonierma,Richard J. FitzGerald
出处
期刊:Journal of Food Biochemistry [Wiley]
卷期号:43 (1): e12451-e12451 被引量:160
标识
DOI:10.1111/jfbc.12451
摘要

Dipeptidyl peptidase IV (DPP-IV) is involved in incretin hormone processing and therefore plays a key role in glycemic regulation. This review summarizes the latest developments in food protein-derived DPP-IV inhibitory peptides. The in silico approaches currently used to develop targeted strategies for the enzymatic release of DPP-IV inhibitory peptides from food proteins are outlined. The features within the primary sequences of potent DPP-IV inhibitory di-, tri-, and larger peptides, having half maximal inhibitory activity (IC50 ) < 100 µM, were evaluated and the outcomes are presented herein. It is proposed that detailed analysis of those food derived peptides identified in humans following ingestion may constitute a practical strategy for the targeted identification of novel bioavailable DPP-IV inhibitory peptides. Human intervention studies are required as the specific role of food protein-derived DPP-IV inhibitory peptides in the regulation of glycaemia in humans remains to be fully elucidated. PRACTICAL APPLICATIONS: This review provides recent information on dipeptidyl peptidase IV (DPP-IV) inhibitory peptides arising from food protein hydrolysates. Small animal studies have demonstrated that food protein hydrolysates with in vitro DPP-IV inhibitory properties also display antidiabetic activity. DPP-IV inhibitory peptides may be used as food ingredients to improve glycemic regulation in Type 2 diabetics. Therefore, the development of potent DPP-IV inhibitory hydrolysates containing bioavailable peptides in humans is of significant interest. This may help in the formulation of foods containing physiologically relevant doses of bioactive hydrolysates/peptides. Acquisition of detailed knowledge of DPP-IV inhibitory peptide features via the utilization of in silico tools may help to optimize the release of potent DPP-IV inhibitory peptides during enzymatic hydrolysis of food proteins. This review provides information on features within the primary sequences of potent DPP-IV inhibitory peptides and current in silico strategies which may be used to inform on the targeted enzymatic hydrolysis of food proteins.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
4秒前
鹏程万里发布了新的文献求助10
5秒前
5秒前
Lionnn完成签到 ,获得积分10
6秒前
8秒前
憨憨发布了新的文献求助10
10秒前
111111完成签到,获得积分10
10秒前
张小龙完成签到 ,获得积分10
11秒前
12秒前
12秒前
可爱的函函应助清爽聋五采纳,获得10
12秒前
加菲丰丰完成签到,获得积分0
12秒前
15秒前
sophieCCM0302发布了新的文献求助10
18秒前
星辰大海应助竹外桃花采纳,获得10
19秒前
小秃兄完成签到,获得积分10
19秒前
20秒前
and999完成签到,获得积分10
21秒前
23秒前
小马到处跑完成签到,获得积分10
24秒前
尼莫发布了新的文献求助10
26秒前
sophieCCM0302完成签到,获得积分10
27秒前
wlz发布了新的文献求助10
29秒前
30秒前
桐桐应助温柔半梦采纳,获得10
30秒前
31秒前
gege完成签到 ,获得积分10
31秒前
申思完成签到,获得积分10
32秒前
34秒前
jieli发布了新的文献求助10
34秒前
36秒前
申思发布了新的文献求助10
37秒前
钦点小黑完成签到 ,获得积分10
37秒前
39秒前
开心完成签到,获得积分10
39秒前
jieli完成签到,获得积分10
40秒前
lalalala发布了新的文献求助10
41秒前
温柔半梦发布了新的文献求助10
44秒前
44秒前
高分求助中
Sustainability in Tides Chemistry 2800
Kinetics of the Esterification Between 2-[(4-hydroxybutoxy)carbonyl] Benzoic Acid with 1,4-Butanediol: Tetrabutyl Orthotitanate as Catalyst 1000
The Young builders of New china : the visit of the delegation of the WFDY to the Chinese People's Republic 1000
Rechtsphilosophie 1000
Bayesian Models of Cognition:Reverse Engineering the Mind 888
Handbook of Qualitative Cross-Cultural Research Methods 600
Very-high-order BVD Schemes Using β-variable THINC Method 568
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3137638
求助须知:如何正确求助?哪些是违规求助? 2788565
关于积分的说明 7787590
捐赠科研通 2444902
什么是DOI,文献DOI怎么找? 1300139
科研通“疑难数据库(出版商)”最低求助积分说明 625814
版权声明 601023