药物输送
药品
吸入
医学
沉积(地质)
晶体工程
纳米技术
重症监护医学
药理学
材料科学
化学
生物
晶体结构
有机化学
麻醉
超分子化学
古生物学
沉积物
作者
Preshita Desai,Sanyat S. Mapara,Vandana Patravale
标识
DOI:10.2174/1381612824666180518080948
摘要
Background and objective: Pulmonary drug delivery has transformed over a past few decades from being a platform for local pulmonary disease treatment to systemic drug delivery opportunities. In case of pulmonary delivery systems, particle properties are critical as they affect inhalation efficacy, pulmonary deposition, drug delivery and overall performance. With this in view, particle engineering has emerged as an advanced science that helps in designing of efficacious pulmonary delivery systems. Among various particle engineering branches, crystal engineering is being extensively explored as it provides an opportunity to optimize particles at morphological, physicochemical and molecular levels which are essential to understand the role of crystal engineering in pulmonary drug delivery. Methods: A thorough literature survey in the field of crystal engineering approaches explored for pulmonary drug delivery was conducted and the collected data was meticulously studied and summarized. Results: In the review, pulmonary system is discussed with respect to various sites for drug deposition in respiratory tract, mechanism of drug deposition and clearance. Further, critical crystal parameters are discussed in-depth and various crystal engineering methods are summarized with emphasis on their impact on pulmonary delivery. Also, inhalation devices are overviewed to understand their performance in relation to crystal based pulmonary formulations. Conclusion: The review enabled a detailed insight on crystal engineering approaches for design of pulmonary delivery systems.
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