阿尔戈瑙特
生物
基因沉默
Piwi相互作用RNA
拉西尔纳
细胞生物学
RNA诱导沉默复合物
RNA干扰
计算生物学
基因
核糖核酸
遗传学
作者
Jessica Sheu‐Gruttadauria,Ian J. MacRae
标识
DOI:10.1016/j.jmb.2017.07.018
摘要
Nearly every cell in the human body contains a set of programmable gene-silencing proteins named Argonaute. Argonaute proteins mediate gene regulation by small RNAs and thereby contribute to cellular homeostasis during diverse physiological process, such as stem cell maintenance, fertilization, and heart development. Over the last decade, remarkable progress has been made toward understanding Argonaute proteins, small RNAs, and their roles in eukaryotic biology. Here, we review current understanding of Argonaute proteins from a structural prospective and discuss unanswered questions surrounding this fascinating class of enzymes.
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