Associations Between Tau, β-Amyloid, and Cognition in Parkinson Disease

痴呆 匹兹堡化合物B 磁共振成像 帕金森病 认知 正电子发射断层摄影术 医学 疾病 路易氏体型失智症 认知障碍 心理学 内科学 神经影像学 蒙特利尔认知评估 核医学 精神科 放射科
作者
Joseph R. Winer,Anne Maaß,Peter Pressman,Jordan Stiver,Daniel R. Schonhaut,Suzanne L. Baker,Joel H. Kramer,Gil D. Rabinovici,William J. Jagust
出处
期刊:JAMA Neurology [American Medical Association]
卷期号:75 (2): 227-227 被引量:62
标识
DOI:10.1001/jamaneurol.2017.3713
摘要

Multiple disease processes are associated with cognitive impairment in Parkinson disease (PD), including Lewy bodies, cerebrovascular disease, and Alzheimer disease. It remains unknown whether tau pathology relates to cognition in patients with PD without dementia.To compare tau aggregation in patients with PD who are cognitively normal (PD-CN), patients with PD with mild cognitive impairment (PD-MCI), and healthy control participants, and evaluate the relationships between β-amyloid (Aβ), tau, and cognition in patients with PD who did not have dementia.This cross-sectional study recruited 30 patients with Parkinson disease (15 with PD-CN and 15 with PD-MCI) from a tertiary care medical center and research institutions from July 2015 through October 2016. One patient with PD-MCI did not receive a magnetic resonance imaging scan and thus was excluded from all analyses; 29 patients with PD were included in the present study. Participants underwent tau positron emission tomographic (PET) scanning with fluorine 18-labeled AV-1451, Aβ PET scanning with carbon 11-labeled Pittsburgh compound B, magnetic resonance imaging, cognitive testing, and neurologic evaluation. Imaging measures were compared with 49 healthy control participants.Outcomes were tau PET measurements of groups of patients with PD-CN and PD-MCI. We hypothesized that tau aggregation across groups would be related to age and Aβ status.Of the 78 participants, 47 (60%) were female, and the mean (SD) age was 71.1 (6.6) years. Six patients with PD (21%) were Aβ-positive, of whom 1 was mildly cognitively impaired; 23 were Aβ-negative (79%). (Of the 49 healthy controls, 25 were Aβ-negative and 24 Aβ-positive.) Voxelwise contrasts of whole-brain tau PET uptake between patients with PD-CN and patients with PD-MCI, and additionally between all patients with PD and Aβ-negative controls, did not reveal significant differences. Tau PET binding did not differ between patients with PD-MCI and PD-CN in brain regions reflecting Alzheimer disease Braak stages 1/2, 3/4, or 5/6, and did not differ from Aβ-negative healthy older adults. Mean (SD) tau PET binding was significantly elevated in Aβ-positive patients with PD relative to Aβ-negative patients with PD within brain regions reflecting Alzheimer disease Braak stage 3/4 (1.22 [0.07] vs 1.14 [0.07]; P = .03) and Braak stage 5/6 (1.20 [0.07] vs 1.11 [0.08]; P = .02).These findings suggest that patterns of cortical Aβ and tau do not differ in people with PD-CN, people with PD-MCI, and healthy older adults. Age, Aβ, and tau do not differentiate patients with PD-CN and PD-MCI. Tau deposition is related to Aβ status and age in both people with PD and healthy older adults. Cognitive deficits in people with PD without dementia do not appear to reflect measureable Alzheimer disease.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
Hello应助范先生采纳,获得10
刚刚
zpbb完成签到,获得积分10
1秒前
1秒前
2秒前
肖遥完成签到,获得积分10
2秒前
111发布了新的文献求助10
3秒前
小闵完成签到,获得积分10
3秒前
小蘑菇应助胡树采纳,获得10
3秒前
5秒前
5秒前
5秒前
威武雪兰完成签到,获得积分10
5秒前
5秒前
一坨完成签到 ,获得积分10
5秒前
科研通AI5应助net80yhm采纳,获得10
6秒前
lh发布了新的文献求助10
7秒前
Einson完成签到 ,获得积分10
8秒前
lx发布了新的文献求助10
8秒前
001完成签到,获得积分10
9秒前
开着飞机骑拖拉机完成签到,获得积分10
9秒前
寇婧怡完成签到 ,获得积分10
10秒前
阿湫发布了新的文献求助10
10秒前
Qsss发布了新的文献求助10
10秒前
10秒前
11秒前
JamesPei应助111采纳,获得10
11秒前
执笔完成签到,获得积分10
11秒前
手可摘星辰完成签到 ,获得积分10
12秒前
量子星尘发布了新的文献求助10
12秒前
李健应助大帅采纳,获得10
13秒前
14秒前
冷艳的火龙果完成签到,获得积分10
14秒前
不知完成签到 ,获得积分10
14秒前
Zard发布了新的文献求助10
16秒前
清仔发布了新的文献求助10
16秒前
17秒前
大地上的鱼完成签到,获得积分10
17秒前
17秒前
上官若男应助平常的路人采纳,获得10
17秒前
小花发布了新的文献求助10
18秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
Research on Disturbance Rejection Control Algorithm for Aerial Operation Robots 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038524
求助须知:如何正确求助?哪些是违规求助? 3576221
关于积分的说明 11374737
捐赠科研通 3305912
什么是DOI,文献DOI怎么找? 1819354
邀请新用户注册赠送积分活动 892688
科研通“疑难数据库(出版商)”最低求助积分说明 815048