新生儿Fc受体
白蛋白
药代动力学
血清白蛋白
药理学
人血清白蛋白
受体
血浆蛋白结合
人白蛋白
计算生物学
生物
化学
生物化学
免疫学
免疫球蛋白G
抗体
作者
Jeannette Nilsen,Inger Sandlie,Derry C. Roopenian,Jan Terje Andersen
标识
DOI:10.1016/j.coche.2017.11.007
摘要
Albumin has a long serum half-life due to its unique ability to bind the cellular neonatal Fc receptor (FcRn), which provides protection from intracellular degradation. The interaction can be capitalized to improve the efficacy of drugs by extending their serum persistence. However, species-specific binding of albumin to FcRn challenges preclinical development. The goal of this brief review is to provide insights into how FcRn and cross-species binding differences affect the pharmacokinetics of human serum albumin (HSA) in different animal models, and gives an overview of genetically modified mice that may serve as improved models for testing of albumin-based drugs.
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