周围神经损伤
脂肪组织
神经干细胞
干细胞
医学
组织工程
神经导管
神经组织工程
外围设备
神经损伤
周围神经
神经科学
病理
生物医学工程
外科
解剖
细胞生物学
生物
内科学
作者
Ming Li,Peixun Zhang,Dianying Zhang
标识
DOI:10.1016/j.mehy.2018.02.027
摘要
Peripheral nerve injury is a common trauma disease which often results in sensory and motor dysfunction. However, the surgical repair for peripheral nerve injury, especially for large segmental defects, is not satisfactory. Growing evidences suggest that artificial neural conduit combined with stem cells is potential tissue engineering remediation method for peripheral nerve injury. But, selections of biomaterials and stem cells are still being debated. Based on the findings from previous studies, we hypothesize that PVDF piezoelectric neural conduit incorporated Schwann-like cells which pre-differentiated from adipose-derived stem cells may substantially promote the repair of peripheral nerve injury. This novel technique may help clinical surgeons cure the seriously injured patients better and point out a new direction for neural tissue engineering researchers select the suitable biomaterials and seed cells.
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