化学
共价键
共价结合
药物发现
计算生物学
组合化学
血浆蛋白结合
小分子
生物化学
有机化学
生物
作者
Christian M. Pichler,Joanna Krysiak,Rolf Breinbauer
标识
DOI:10.1016/j.bmc.2016.03.050
摘要
The characterization of the target proteins of drug molecules has become an important goal in understanding its mode of action and origin of side effects due to off-target binding. This is especially important for covalently binding drugs usually containing electrophilic moieties, which potentially can react with nucleophilic residues found in many proteins. This review gives a comprehensive overview of the use of activity-based protein profiling (ABPP) as an efficient tool for the target identification of covalently binding drugs.
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