Synergistic effects of jujuba polysaccharide on Lentinan in anti-fatigue & antioxidant activities

To investigate the synergistic effect of jujuba polysaccharide(JDP) on Lentinan(LNT) in antifatigue antioxidant activities, JDP and LNT compounds of low, middle and high dosage were adopted in the mice anti-fatigue antioxidant function, compared with control group. After 30 days loaded mice swimming experiment was done, and after 40 days CAT, scavenging ·OH, GSH-PX, SOD and MDA abilities of blood and liver were measured. The results demonstrated that the optimum proportion was JDP:LNT=3:7. According to loaded mice swimming experiment, JDP and LNT compounds of high dosage(100 mg/kg)(79.26±0.39) min and LNT control group(52.15±1.57) min increased significantly (p0.05), LNT with JDP could obviously prolong the swimming time of loaded mice. As for the antioxidant experiment, JDP and LNT compounds could enhance the CAT, GSH-PX and SOD activities of mice blood and liver, and decrease the ·OH ability and MDA content. Compared with LNT control group, high dosage markedly enhanced the activities of GSH-PX and SOD in blood and liver, and middle dosage significantly increased CAT activity in liver. It showed that JDP on LNT had obvious improvement in the anti-fatigue antioxidant function.