Isolation and identification of brominated alkaloids from the Turkish sponge Ircinia variabilis

Objective To study the chemical constituents of the marine sponge Ircinia variabilis collected from the Turgut Reis coast.Methods The chemical constituents were isolated by various methods of isolation and their structures were elucidated by physicochemical properties and the analysis of spectral data compared with those reported in literatures.Results Five alkaloids were isolated and identified as fistularin-3(1),2-oxazolidinone(2),(E)-1-acetamide-3,5-dibromo-4-ethoxy4-methoxy-1-Hydroxy-2,5-cyclohexaddienone(3),(Z)-1-acetamide-3,5-dibromo-4-ethoxy-4-methoxy-1-hydroxy-2,5-cyclohexaddienone(4),and 3,5-dibromotyrosine(5).Conclusion Compound 2-4 have benn isolated from the sponge Ircinia variabilis for the first time.