[Lipoprotein (a) in a population-based study: more significant in Turkish women than men?].

医学 内科学 血压 内分泌学 腰围 代谢综合征 脂蛋白 逻辑回归 土耳其人 胆固醇 人口 肥胖 生物 生物化学 环境卫生 基因型 基因
作者
Altan Onat,Mehmet Yazıcı,Gülay Hergenç,Yüksel Doğan,Ahmet Karabulut,İbrahim Sarı,Serdar Türkmen,Günay Can,Vedat Sansoy
出处
期刊:PubMed 卷期号:5 (4): 271-7 被引量:4
链接
标识
摘要

Serum lipoprotein(a) [Lp(a)] concentrations, determined in 665 persons in the 2003/04 survey of the Turkish Adult Risk Factor Study, were investigated in regard to distribution, determinants and relationship to cardiovascular risk factors, metabolic syndrome (MS) and coronary heart disease (CHD).Diagnosis of MS was based on Adult Treatment Panel III criteria, that of CHD on the presence of clinical findings and Minnesota coding of resting electrocardiograms. Metabolic syndrome was observed in 44%, CHD in 14% of the study sample. Behring nephelometry was used for Lp(a) values measurements which were log-transformed for analyses because of skewing.Geometric mean values of Lp(a) in 286 men and 379 women, aged 55.5 +/-12.0 years, were 9.46+/-2.90 mg/dL and 10.46+/-3.00 mg/dL (p>0.2), respectively. Apart from a slight correlation with age, Lp(a) exhibited significant positive correlations with apolipoproteins A-I and B, low density lipoprotein-cholesterol (LDL-C) (r =0.15), total cholesterol, high density lipoprotein-cholesterol (HDL-C), systolic blood pressure and log C-reactive protein, and inverse ones with thyroid stimulating hormone (r =-0.25) in men, and log gamma glutamyltransferase in women. Further 10 variables were not significantly correlated in either gender. In linear regression analyses for independent covariates of Lp(a), positive associations were noted with serum total cholesterol and systolic blood pressure, and inverse ones with waist circumference, triglycerides and (only in women) with gamma glutamyltransferase. Logistic regression analyses revealed in men no association with either MS or CHD likelihood. Among women, age-adjusted Lp(a) was associated inversely at a borderline significance with MS, as did levels of Lp(a) >30 mg/dl vs. the remaining sample, controlled for age and MS, display an odds ratio (OR) of 1.62 for prevalent CHD (p=0.20). An OR of 1.92 (p<0.19) was noted in all adults for the coexistence of Lp(a) >30 mg/dl and LDL-C >150 mg/dl, after controlling for age, MS, smoking status and LDL-C categories.Lipoprotein(a), the variance of which is known to be overwhelmingly due to the apo(a) isoforms, proved to have a significant inverse independent association with a measure of abdominal obesity. Lipoprotein(a) levels appeared not to be associated with risk for MS or CHD among men. In women, however, high Lp(a) levels were accompanied with an environment less prone to MS, and - without attaining significance -- tended to be associated with CHD likelihood, independent of age and MS. Further studies are warranted in this area.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
qingchenwuhou完成签到 ,获得积分10
1秒前
XXX完成签到,获得积分10
2秒前
锡嘻完成签到 ,获得积分10
2秒前
3秒前
彗星入梦完成签到 ,获得积分10
3秒前
恋恋青葡萄完成签到,获得积分10
3秒前
隐形万言完成签到,获得积分10
5秒前
Time完成签到,获得积分10
5秒前
土木研学僧完成签到,获得积分10
6秒前
yjy完成签到 ,获得积分10
6秒前
A溶大美噶完成签到,获得积分10
6秒前
yar应助萨尔莫斯采纳,获得10
7秒前
Will发布了新的文献求助10
7秒前
美好的鹏笑完成签到,获得积分10
9秒前
啦啦啦啦啦完成签到,获得积分10
9秒前
LYegoist完成签到,获得积分10
11秒前
可爱的小丸子完成签到,获得积分10
11秒前
一川烟叶完成签到,获得积分10
13秒前
13秒前
16秒前
iFan完成签到 ,获得积分10
16秒前
萨尔莫斯完成签到,获得积分10
16秒前
合适靖儿完成签到 ,获得积分10
18秒前
林林林完成签到,获得积分10
19秒前
斯琪欣完成签到,获得积分10
20秒前
21秒前
MQQ完成签到 ,获得积分10
21秒前
meng发布了新的文献求助10
21秒前
22秒前
zxc167完成签到,获得积分10
22秒前
研友_nVWP2Z完成签到 ,获得积分10
24秒前
俭朴的半雪完成签到 ,获得积分10
25秒前
大橙子发布了新的文献求助10
26秒前
meng完成签到,获得积分10
27秒前
28秒前
28秒前
科研韭菜完成签到 ,获得积分10
28秒前
SYLJ完成签到,获得积分10
30秒前
灵巧的十八完成签到 ,获得积分10
31秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Handbook of Industrial Diamonds.Vol2 1100
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038201
求助须知:如何正确求助?哪些是违规求助? 3575940
关于积分的说明 11373987
捐赠科研通 3305747
什么是DOI,文献DOI怎么找? 1819274
邀请新用户注册赠送积分活动 892662
科研通“疑难数据库(出版商)”最低求助积分说明 815022