作者
Nicolas Stransky,Mahmoud Ghandi,Gregory V. Kryukov,Levi A. Garraway,Arnaud Amzallag,Iulian Pruteanu-Malinici,Daniel A. Haber,Sridhar Ramaswamy,Cyril H. Benes,Joseph Lehar,Manway Liu,Dmitriy Sonkin,Audrey Kauffmann,Kavitha Venkatesan,Elena J. Edelman,Markus Riester,Jordi Barretina,Giordano Caponigro,Robert A. Schlegel,William R. Sellers,Frank Stegmeier,Michael T. Morrissey,Michael P. Menden,Francesco Iorio,Michael R. Stratton,Michael W. McDermott,Julio Saez-Rodriguez,Mathew J. Garnett
摘要
Large cancer cell line collections broadly capture the genomic diversity of human cancers and provide valuable insight into anti-cancer drug response. Here we show substantial agreement and biological consilience between drug sensitivity measurements and their associated genomic predictors from two publicly available large-scale pharmacogenomics resources: The Cancer Cell Line Encyclopedia and the Genomics of Drug Sensitivity in Cancer databases.