生物
去甲基化
连环素
癌症研究
信使核糖核酸
宫颈癌
DNA甲基化
Wnt信号通路
内科学
细胞生物学
宫颈癌
癌症
基因表达
信号转导
基因
遗传学
医学
作者
Shun Zhou,Zhoulan Bai,Di Xia,Zhijun Zhao,Ren Zhao,Yan‐Yang Wang,Hong Zhe
摘要
The role of N6 -methyladenosine (m6 A) demethylase fat mass and obesity-associated protein (FTO) in the regulation of chemo-radiotherapy resistance remains largely unknown. Here, we show that the mRNA level of FTO is elevated in cervical squamous cell carcinoma (CSCC) tissues when compared with respective adjacent normal tissues. FTO enhances the chemo-radiotherapy resistance both in vitro and in vivo through regulating expression of β-catenin by reducing m6 A levels in its mRNA transcripts and in turn increases excision repair cross-complementation group 1 (ERCC1) activity. Clinically, the prognostic value of FTO for overall survival is found to be dependent on β-catenin expression in human CSCC samples. Taken together, these findings uncover a critical function for FTO and its substrate m6 A in the regulation of chemo-radiotherapy resistance, which may bear potential clinical implications for CSCC treatment.
科研通智能强力驱动
Strongly Powered by AbleSci AI