血小板
微泡
外渗
血小板增多症
转移
癌变
癌症
癌症研究
免疫学
限制
免疫监视
医学
癌细胞
血小板活化
生物
肿瘤细胞
内科学
小RNA
工程类
基因
机械工程
生物化学
作者
Monika Haemmerle,Rebecca L. Stone,David G. Menter,Vahid Afshar‐Kharghan,Anil K. Sood
出处
期刊:Cancer Cell
[Elsevier]
日期:2018-04-12
卷期号:33 (6): 965-983
被引量:458
标识
DOI:10.1016/j.ccell.2018.03.002
摘要
Besides their function in limiting blood loss and promoting wound healing, experimental evidence has highlighted platelets as active players in all steps of tumorigenesis including tumor growth, tumor cell extravasation, and metastasis. Additionally, thrombocytosis in cancer patients is associated with adverse patient survival. Due to the secretion of large amounts of microparticles and exosomes, platelets are well positioned to coordinate both local and distant tumor-host crosstalk. Here, we present a review of recent discoveries in the field of platelet biology and the role of platelets in cancer progression as well as challenges in targeting platelets for cancer treatment.
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