全国健康与营养检查调查
医学
四分位间距
脂肪肝
硒
内科学
体质指数
胃肠病学
横断面研究
生理学
酒精性肝病
疾病
病理
环境卫生
人口
肝硬化
化学
有机化学
作者
Xin Wang,Young Ah Seo,Sung Kyun Park
出处
期刊:Environmental health perspectives
[Environmental Health Perspectives]
日期:2021-08-23
卷期号:2021 (1)
被引量:6
标识
DOI:10.1289/isee.2021.p-160
摘要
BACKGROUND AND AIM: Selenium is an essential trace element that shows beneficial or adverse health effects depending on the dose. Laboratory studies suggest that high selenium may contribute to the development of non-alcoholic fatty liver disease (NAFLD). However, human evidence is limited. We evaluated the associations of serum selenium level with serum alanine aminotransferase (ALT) activity and suspected NAFLD prevalence in U.S. adults. METHODS: We conducted the cross-sectional analysis in 3,827 adults aged 20 years and older without viral hepatitis, hemochromatosis, or alcoholic liver disease who participated in the National Health and Nutrition Examination Survey (NHANES) 2011-2012, 2013-2014, and 2015-2016. Serum selenium was measured using inductively coupled plasma dynamic reaction cell mass spectrometry. Suspected NAFLD cases were defined in the presence of serum ALT 30 IU/L in men and 19 IU/L in women in the absence of other identifiable causes of liver disease. RESULTS:The median (interquartile range) of serum selenium level was 127.9 (117.9, 139.4) µg/L. Non-linear associations of serum selenium with NAFLD prevalence and serum ALT activity were observed in the generalized additive models with penalized splines. After adjustment for sociodemographic variables, lifestyle factors, body mass index, and NHANES survey cycles, positive associations were found at ~130 µg/L serum selenium with both NAFLD and ALT, whereas the associations were flattened at ~130 µg/L. CONCLUSIONS:Our findings provide evidence of non-linear associations of serum selenium with ALT activity and NAFLD prevalence. In particular, positive associations were found above serum selenium level of 130 µg/L, whereas no association was observed below this value. This finding requires confirmation in future prospective cohort studies. KEYWORDS: selenium, NAFLD, alanine aminotransferase, nutrients.
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