医学
细胞减少
不利影响
内科学
胃肠病学
移植物抗宿主病
临床终点
耐火材料（行星科学）
外科
疾病
临床试验
天体生物学
物理
骨髓
作者
Madan Jagasia,Aleksandr Lazaryan,Carlos Bachier,Amandeep Salhotra,Daniel J. Weisdorf,Behyar Zoghi,James Essell,Laurie Green,Olivier Schueller,Jeegar Patel,Alexandra Zanin‐Zhorov,Jonathan M. Weiss,Zhongming Yang,David Eiznhamer,Sanjay Aggarwal,Bruce R. Blazar,Stephanie J. Lee
摘要
The rho-associated coiled-coil-containing protein kinase-2 (ROCK2) signaling pathway regulates the Th17/regulatory T cells balance and controls profibrotic pathways. Selective ROCK2 inhibition with belumosudil (KD025) may offer a novel approach to the management of chronic graft-versus-host disease (cGVHD).
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