1288-PUB: Acute Inflammatory Response of Breaking Up Prolonged Sitting with Stair Climbing Exercise Snacks

医学 超重 攀登 内科学 升糖指数 肥胖 血糖性 物理疗法 内分泌学 胰岛素 生物 生态学 病理
作者
Carolina Cabral‐Santos,Hossein Rafiei,Fábio Santos Lira,Jonathan P. Little
出处
期刊:Diabetes [American Diabetes Association]
卷期号:70 (Supplement_1) 被引量:1
标识
DOI:10.2337/db21-1288-pub
摘要

Understand the acute inflammatory disturbances is important for preventing early diabetes and obesity-related complications. This study aimed to determine whether breaking up prolonged sitting into brief several shorter bouts spread throughout the day (“exercise snacks”) associated a short-term dietary intervention (low- or high-carbohydrate) have the potential to alter the acute inflammatory response. Ten male and female healthy weight (Lean) and overweight-obese (OW) participants were randomized to non-training control group with either low-carbohydrate snack (9h sitting; LC) or matched for total energy high-carbohydrate snacks consumption (9h; sitting) and a high-carbohydrate snacks consumption plus stair-climbing intervention (8X15-30seconds; ACTIVE). The same high-glycemic index meals were consumed at 0, 3 and 6h at each condition. Blood samples were collected at baseline, 180, 360 and 540 minutes to assess Interleukin-6 (IL-6), Tumor necrosis factor-α (TNF-α) and Salivary Immunoglobulin A (SIgA) levels. Mixed models for repeated measures were undertaken to examine differences according to condition x time and with Bonferroni post-hoc test. Change in TNF-α levels was not different within or between conditions from both Lean and OW group (p=0.512). For IL-6 there were a main effect of time at 540min [X2(11)=23.15; p=0.01] only in HC condition for OW group. Regarding to SIgA, Lean group showed higher level of SIgA on Active compared to LC and HC condition in all time-points (p=0.001). In addition, adults with OW showed elevated SIgA levels on LC and HC condition (p=0.001) when compared with same condition from Lean group. Our data suggests that breaking up nine hours of prolonged sitting implicated in reduction of acute inflammatory IL-6 plasma levels. In addition, acute manipulation on diet (low- and high-carbohydrate) resulted in alterations in the response of SIgA, increasing its levels in overweight/obese adults. Disclosure C. Cabral-santos: None. H. Rafiei: None. F. S. Lira: None. J. P. Little: None. Funding Natural Sciences and Engineering Research Council of Canada; Fundação de Amparo a Pesquisa do Estado de São Paulo (2018/17648-7)
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