Exploring the interactions between Helicobacter pylori (Hp) infection and other risk factors of gastric cancer: A pooled analysis in the Stomach cancer Pooling (StoP) Project

优势比 幽门螺杆菌 癌症 内科学 医学 胃肠病学 置信区间 病例对照研究 胃癌 逻辑回归
作者
Giulia Collatuzzo,Claudio Pelucchi,Eva Negri,Lizbeth López‐Carrillo,Shoichiro Tsugane,Akihisa Hidaka,Gerson S. Hamada,Raúl Ulises Hernández‐Ramírez,Malaquı́as López-Cervantes,Reza Malekzadeh,Farhad Pourfarzi,Lina Mu,Zuo‐Feng Zhang,Nuno Lunet,Carlo La Vecchia,Paolo Boffetta
出处
期刊:International Journal of Cancer [Wiley]
卷期号:149 (6): 1228-1238 被引量:57
标识
DOI:10.1002/ijc.33678
摘要

Helicobacter pylori (Hp) is crucial in gastric carcinogenesis, but infection alone is not a sufficient cause, and the interaction between Hp infection and other risk factors has not been adequately studied. We conducted a pooled analysis of seven case-control studies from the Stomach cancer Pooling (StoP) Project, comprising 1377 cases and 2470 controls, to explore the interaction among Hp infection and tobacco smoking, alcohol drinking, socioeconomic status (SES) and dietary salt intake on the risk of gastric cancer. We estimated summary odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) by multivariate unconditional logistic regression. The analysis showed no consistent interaction between Hp infection and cigarette smoking, while interaction was more than multiplicative for alcohol drinking (OR = 1.38, 95% CI: 1.07-1.77, P-interaction 0.02) and high intake of salt (OR = 2.62, 95% CI: 1.88-3.65, P-interaction = 0.04). The interaction with SES followed the multiplicative model (P = 0.49), resulting in a weakening among infected individuals of the protective effect of high SES among observed Hp-negative individuals. The interactions found were more pronounced in subjects with history of peptic ulcer. The interactions with Hp infection were stronger for cigarette smoking and dietary salt in the case of noncardia cancer, and for alcohol and SES in the case of cardia cancer. No differences were found when stratifying for histologic type. This large-scale study aimed to quantify the interaction between Hp infection and other modifiable risk factors of gastric cancer revealed that the benefit of combined Hp eradication and lifestyle modification on gastric cancer prevention may be larger than commonly appreciated.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
东方越彬发布了新的文献求助10
刚刚
杪夏二八完成签到 ,获得积分10
9秒前
咖啡味椰果完成签到 ,获得积分10
23秒前
24秒前
满满的都是橙汁完成签到,获得积分10
26秒前
Axs完成签到,获得积分10
28秒前
29秒前
高歌猛进发布了新的文献求助10
31秒前
summer完成签到 ,获得积分10
32秒前
海猫食堂完成签到,获得积分10
33秒前
dm完成签到 ,获得积分10
33秒前
zhongu发布了新的文献求助10
35秒前
乔杰完成签到 ,获得积分10
36秒前
是是是WQ完成签到 ,获得积分0
46秒前
小明完成签到 ,获得积分10
47秒前
年轻的醉冬完成签到 ,获得积分10
51秒前
蛋妮完成签到 ,获得积分10
55秒前
那些兔儿完成签到 ,获得积分10
59秒前
1分钟前
hipig发布了新的文献求助10
1分钟前
young完成签到 ,获得积分10
1分钟前
leo完成签到,获得积分10
1分钟前
Deanna完成签到 ,获得积分10
1分钟前
1分钟前
was_3完成签到,获得积分10
1分钟前
要笑cc完成签到,获得积分10
1分钟前
666完成签到 ,获得积分10
1分钟前
binfo发布了新的文献求助10
1分钟前
宣宣宣0733完成签到,获得积分10
1分钟前
胡质斌完成签到,获得积分10
1分钟前
深情安青应助科研通管家采纳,获得30
1分钟前
吴晓娟完成签到 ,获得积分10
1分钟前
隐形曼青应助hipig采纳,获得10
1分钟前
xiang完成签到 ,获得积分10
1分钟前
俊逸吐司完成签到 ,获得积分10
1分钟前
落雪完成签到 ,获得积分10
2分钟前
猪猪想要平静的生活完成签到 ,获得积分10
2分钟前
Wang发布了新的文献求助10
2分钟前
小喵完成签到 ,获得积分10
2分钟前
qiancib202完成签到,获得积分10
2分钟前
高分求助中
Continuum Thermodynamics and Material Modelling 3000
Production Logging: Theoretical and Interpretive Elements 2700
Les Mantodea de Guyane Insecta, Polyneoptera 1000
Structural Load Modelling and Combination for Performance and Safety Evaluation 1000
Conference Record, IAS Annual Meeting 1977 820
電気学会論文誌D(産業応用部門誌), 141 巻, 11 号 510
Typology of Conditional Constructions 500
热门求助领域 (近24小时)
化学 材料科学 生物 医学 工程类 有机化学 生物化学 物理 纳米技术 计算机科学 内科学 化学工程 复合材料 基因 遗传学 物理化学 催化作用 量子力学 光电子学 冶金
热门帖子
关注 科研通微信公众号,转发送积分 3571332
求助须知:如何正确求助?哪些是违规求助? 3141926
关于积分的说明 9444874
捐赠科研通 2843331
什么是DOI,文献DOI怎么找? 1562830
邀请新用户注册赠送积分活动 731326
科研通“疑难数据库(出版商)”最低求助积分说明 718524