Genetic determinism of phage-bacteria coevolution in natural populations

共同进化 决定论 自然(考古学) 生物 进化生物学 细菌 计算生物学
作者
Damien Piel,Maxime Bruto,Yannick Labreuche,François Blanquart,Sabine Chenivesse,Sophie Lepanse,Adèle James,Rubén Barcia-Cruz,Javier Dubert,Bruno Petton,Erica Lieberman,K. Mathias Wegner,Fatima A. Hussain,Kathryn M. Kauffman,Martin F. Polz,David Bikard,Sylvain Gandon,Frédérique Le Roux
出处
期刊:bioRxiv 被引量:1
标识
DOI:10.1101/2021.05.05.442762
摘要

ABSTRACT Coevolution between bacteriophage (or phage) and their bacterial host is thought to be key for the coexistence of these antagonists. Recent studies have revealed the major role of mobile genetic elements in the emergence of phage resistant hosts but how phage escape these defenses in the wild remained to be explored. Here we show a striking parallel in phage evolving counter defenses to host defenses in natural population. We established a large collection of phages and their bacterial hosts and we explored the genetic structure of their interaction. We find that clearly delineated genomic clusters of phage are specific for distinct clades within a bacterial species, Vibrio crassostreae , yet while all phages can adsorb, only a subset of hosts are killed due to intracellular defense mechanisms. Host genomes contain multiple mobile defense genes and susceptibility to phage is negatively correlated with genome size. Phages also display extensive gene content variation, but their genome size remains conserved. We show that this gene content variation in hosts and phage is due to rapid turnover of genes involved in defense and escape, and that by exchanging anti-defense genes, phages irreversibly switch host. This could be indicative of co-evolution following the matching-allele-model of specificity and the spatial and temporal variability of phage infectivity further suggests that negative-frequency dependent selection drives phage-vibrio coevolutionary dynamics. We propose a “pan-escape system” that can be shared among phages by homologous recombination within a population that infects a bacterial host.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
浪麻麻完成签到 ,获得积分10
1秒前
包容的剑完成签到 ,获得积分10
5秒前
等待的大炮完成签到,获得积分10
5秒前
注水萝卜完成签到 ,获得积分10
7秒前
Chem34完成签到,获得积分10
15秒前
17秒前
量子星尘发布了新的文献求助10
17秒前
hhh2018687完成签到,获得积分10
17秒前
17秒前
18秒前
18秒前
18秒前
18秒前
19秒前
19秒前
19秒前
19秒前
19秒前
19秒前
19秒前
嘒彼小星完成签到 ,获得积分10
19秒前
19秒前
20秒前
20秒前
20秒前
20秒前
21秒前
ri_290完成签到,获得积分10
21秒前
22秒前
nsc发布了新的文献求助30
24秒前
nsc发布了新的文献求助10
24秒前
nsc发布了新的文献求助10
24秒前
nsc发布了新的文献求助10
24秒前
nsc发布了新的文献求助10
24秒前
nsc发布了新的文献求助10
24秒前
nsc发布了新的文献求助10
24秒前
nsc发布了新的文献求助10
24秒前
nsc发布了新的文献求助10
24秒前
nsc发布了新的文献求助10
24秒前
nsc发布了新的文献求助10
24秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Handbook of Industrial Diamonds.Vol2 1100
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038039
求助须知:如何正确求助?哪些是违规求助? 3575756
关于积分的说明 11373782
捐赠科研通 3305574
什么是DOI,文献DOI怎么找? 1819239
邀请新用户注册赠送积分活动 892655
科研通“疑难数据库(出版商)”最低求助积分说明 815022