化学
胺化
磷化氢
三联苯
钯
芳基
卤化物
催化作用
配体(生物化学)
卤代芳基
有机化学
腈
组合化学
药物化学
高分子化学
受体
烷基
生物化学
作者
Fabin Zhou,Lixue Zhang,Ji‐Cheng Shi
标识
DOI:10.1016/j.jcat.2021.08.017
摘要
A terphenyl phosphine ligand (2,6-bis(2,4,6-triisopropylphenyl)phenyl-dicyclohexylphosphine, TXPhos) and its supported palladium complex [(TXPhos)(allyl)PdCl] have been developed and the catalyst system is highly efficient in amination of aryl halides with 1° anilines, especially effective for densely functionalized substrates including both partners possessing ortho-ester, acetyl, nitrile and nitro groups. With the TXPhos-supported catalyst system, many partner combinations have been unprecedentedly realized and the base scope has been even extended to KOAc, which is even the best choice in the amination of 2-nitrochlorobenzene.
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