两亲性
纳米技术
高分子
仿生材料
合成生物学
聚合物
合成聚合物
共聚物
化学
纳米颗粒
材料科学
有机化学
计算生物学
生物化学
生物
作者
Meredith H. Barbee,Zoe M. Wright,Benjamin P. Allen,Henry L. Taylor,Emily F. Patteson,Abigail Knight
出处
期刊:Macromolecules
[American Chemical Society]
日期:2021-03-09
卷期号:54 (8): 3585-3612
被引量:42
标识
DOI:10.1021/acs.macromol.0c02826
摘要
Protein-mimetic amphiphiles have significant promise as a platform to access the complex functions of natural biological materials and incorporate the tunability and environmental resilience of synthetic materials. The fields of polymer chemistry and chemical biology have concurrently approached the development of biomimetic amphiphiles with materials ranging from random amphiphilic copolymers to peptide–lipid conjugates. In this Perspective, we incorporate strategies from diverse chemical arenas for controlling assembled morphologies and dynamics of protein-mimetic synthetic macromolecules. An overview of significant advances in peptide amphiphiles and single-chain polymer nanoparticles provides the foundation for comparing recent advances in the implementation of multiple intermolecular interactions and computational strategies to fine-tune the assembled structures. We aim to bridge these fields, combining insights from multiple disciplines to inspire new approaches for the development of protein-mimetic materials, as these assemblies have far-reaching applications including in the development of new sensors, catalysts, and therapeutics.
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