Self-assembled nanomedicine combining a berberine derivative and doxorubicin for enhanced antitumor and antimetastatic efficacyviamitochondrial pathways

A self-assembled nanomedicine combining Ber and Dox with high drug loading was developed, which could translocate Dox from the nucleus to mitochondria and finally inhibit tumor proliferation and metastasis simultaneouslyviamitochondrial pathways.