Review—Recent Advance in Multi-Metallic Metal Organic Frameworks (MM-MOFs) and Their Derivatives for Electrochemical Biosensor Application

The recent trend on metal organic framework (MOF) studies has shifted to the development of MOFs with many metal nodes, also known as multi metallic MOF (MM-MOF). Many studies have shown that MM-MOF display much better performance compared to single metallic MOFs. In addition, derived MM-MOF products such as metal hybrids, MM-MOF composites, and MOF-on-MOF also provide interesting unique characteristics. In this review, we summarize the synthesis strategy of MM-MOF and their derivates in three different approaches, including one-pot synthesis/direct mixing, post-synthesis modification, and MOFs derivative preparation. In many applications, such as cancer markers detection, diabetic disease detection, metabolic disease detection, infectious disease detection, and toxic pollutant detection, MM-MOF based biosensors displayed excellent sensing performance as well as stability, selectivity, and reproducibility. This review provides a point of view on the recent development, preparation, and application of MM-MOF including the challenge and future prospect of this material.