清晨好,您是今天最早来到科研通的研友!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您科研之路漫漫前行!

Efficacy and safety of high-dose esomeprazole–amoxicillin dual therapy for Helicobacter pylori rescue treatment: a multicenter, prospective, randomized, controlled trial

埃索美拉唑 医学 阿莫西林 内科学 幽门螺杆菌 胃肠病学 呋喃唑酮 意向治疗分析 不利影响 随机对照试验 临床终点 抗生素 微生物学 生物
作者
Hanxin Bi,Xingxing Chen,Yuxin Chen,Xin Zhao,Shasha Wang,Jiehong Wang,Ting Lyu,Shuang Han,Tao Lin,Mingquan Li,Donghong Yuan,Junye Liu,Yongquan Shi
出处
期刊:Chinese Medical Journal [Ovid Technologies (Wolters Kluwer)]
卷期号:135 (14): 1707-1715 被引量:21
标识
DOI:10.1097/cm9.0000000000002289
摘要

High-dose dual therapy (HDDT) with proton pump inhibitors (PPIs) and amoxicillin has attracted widespread attention due to its favorable efficacy in eradicating Helicobacter pylori (H. pylori). This study aimed to compare the efficacy and safety of high-dose PPI-amoxicillin dual therapy and bismuth-containing quadruple therapy for H. pylori rescue treatment.This was a prospective, randomized, multicenter, non-inferiority trial. Patients recruited from eight centers who had failed previous treatment were randomly (1:1) allocated to two eradication groups: HDDT (esomeprazole 40 mg and amoxicillin 1000 mg three times daily; the HDDT group) and bismuth-containing quadruple therapy (esomeprazole 40 mg, bismuth potassium citrate 220 mg, and furazolidone 100 mg twice daily, combined with tetracycline 500 mg three times daily; the tetracycline, furazolidone, esomeprazole, and bismuth [TFEB] group) for 14 days. The primary endpoint was the H. pylori eradication rate. The secondary endpoints were adverse effects, symptom improvement rates, and patient compliance.A total of 658 patients who met the criteria were enrolled in this study. The HDDT group achieved eradication rates of 75.4% (248/329), 81.0% (248/306), and 81.3% (248/305) asdetermined by the intention-to-treat (ITT), modified intention-to-treat (MITT), and per-protocol (PP) analyses, respectively. The eradication rates were similar to those in the TFEB group: 78.1% (257/329), 84.2% (257/305), and 85.1% (257/302). The lower 95% confidence interval boundary (-9.19% in the ITT analysis, - 9.21% in the MITT analysis, and -9.73% in the PP analysis) was greater than the predefined non-inferiority margin of -10%, establishing a non-inferiority of the HDDT group vs. the TFEB group. The incidence of adverse events in the HDDT group was significantly lower than that in the TFEB group (11.1% vs. 26.8%, P < 0.001). Symptom improvement rates and patients' compliance were similar between the two groups.Fourteen-day HDDT is non-inferior to bismuth-containing quadruple therapy, with fewer adverse effects and good treatment compliance, suggesting HDDT as an alternative for H. pylori rescue treatment in the local region.Clinicaltrials.gov, NCT04678492.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
科研通AI2S应助科研通管家采纳,获得10
1秒前
酷波er应助一个小胖子采纳,获得10
11秒前
DongWei95应助一个小胖子采纳,获得10
29秒前
JamesPei应助Mannone采纳,获得10
31秒前
38秒前
学习发布了新的文献求助10
39秒前
川藏客完成签到 ,获得积分10
44秒前
耶耶耶完成签到 ,获得积分10
51秒前
51秒前
Mannone完成签到,获得积分10
53秒前
传奇3应助一个小胖子采纳,获得10
56秒前
Mannone发布了新的文献求助10
57秒前
学习完成签到,获得积分10
1分钟前
李爱国应助一个小胖子采纳,获得10
1分钟前
CipherSage应助一个小胖子采纳,获得10
1分钟前
1分钟前
JamesPei应助一个小胖子采纳,获得10
1分钟前
orixero应助一个小胖子采纳,获得10
1分钟前
2分钟前
chencc13发布了新的文献求助10
2分钟前
乐乐应助一个小胖子采纳,获得10
2分钟前
丘比特应助一个小胖子采纳,获得10
2分钟前
一个小胖子完成签到,获得积分10
2分钟前
vitamin完成签到 ,获得积分10
3分钟前
顾矜应助Kumquat采纳,获得10
4分钟前
王老板发布了新的文献求助10
4分钟前
4分钟前
4分钟前
思源应助瘦瘦的涵瑶采纳,获得10
4分钟前
一兜兜糖完成签到,获得积分10
4分钟前
5分钟前
Kumquat发布了新的文献求助10
5分钟前
lanxinge完成签到 ,获得积分10
5分钟前
城外青山完成签到,获得积分10
5分钟前
nuliguan完成签到 ,获得积分10
5分钟前
5分钟前
风中凡霜发布了新的文献求助10
5分钟前
友好擎发布了新的文献求助50
6分钟前
风中凡霜完成签到,获得积分10
6分钟前
犹豫翠萱完成签到 ,获得积分10
6分钟前
高分求助中
Sustainability in ’Tides Chemistry 2000
Studien zur Ideengeschichte der Gesetzgebung 1000
The ACS Guide to Scholarly Communication 1000
TM 5-855-1(Fundamentals of protective design for conventional weapons) 1000
Handbook of the Mammals of the World – Volume 3: Primates 805
Ethnicities: Media, Health, and Coping 800
Gerard de Lairesse : an artist between stage and studio 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3072750
求助须知:如何正确求助?哪些是违规求助? 2726364
关于积分的说明 7493832
捐赠科研通 2374266
什么是DOI,文献DOI怎么找? 1258931
科研通“疑难数据库(出版商)”最低求助积分说明 610422
版权声明 596997