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HomeCirculationVol. 147, No. 16How Low Can You Go? New Evidence Supports No Lower Bound to Low-Density Lipoprotein Cholesterol Level in Secondary Prevention No AccessEditorialRequest AccessFull TextAboutView Full TextView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toNo AccessEditorialRequest AccessFull TextHow Low Can You Go? New Evidence Supports No Lower Bound to Low-Density Lipoprotein Cholesterol Level in Secondary Prevention Fatima Rodriguez and Amit Khera Fatima RodriguezFatima Rodriguez https://orcid.org/0000-0002-5226-0723 Department of Internal Medicine, Division of Cardiology and the Cardiovascular Institute, Stanford University, CA (F.A.). Search for more papers by this author and Amit KheraAmit Khera Correspondence to: Amit Khera, MD, MSc, Division of Cardiology, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390-8830. Email E-mail Address: [email protected] https://orcid.org/0000-0001-7255-6874 Department of Internal Medicine, Division of Cardiology, UT Southwestern Medical Center, Dallas, TX (A.K.). Search for more papers by this author Originally published17 Apr 2023https://doi.org/10.1161/CIRCULATIONAHA.123.064041Circulation. 2023;147:1204–1207This article is a commentary on the followingAssociation Between Achieved Low-Density Lipoprotein Cholesterol Levels and Long-Term Cardiovascular and Safety Outcomes: An Analysis of FOURIER-OLEFootnotesThe opinions expressed in this article are not necessarily those of the editors or of the American Heart Association.For Sources of Funding and Disclosures, see page 1207.Circulation is available at www.ahajournals.org/journal/circCorrespondence to: Amit Khera, MD, MSc, Division of Cardiology, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390-8830. Email amit.[email protected]eduReferences1. Cleeman JI, Lenfant C. 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Comparison of low-density lipoprotein cholesterol assessment by Martin/Hopkins estimation, Friedewald estimation, and preparative ultracentrifugation: insights from the FOURIER trial.JAMA Cardiol. 2018; 3:749–753. doi: 10.1001/jamacardio.2018.1533CrossrefMedlineGoogle Scholar Previous Back to top Next FiguresReferencesRelatedDetailsRelated articlesAssociation Between Achieved Low-Density Lipoprotein Cholesterol Levels and Long-Term Cardiovascular and Safety Outcomes: An Analysis of FOURIER-OLEPrakriti Gaba, et al. Circulation. 2023;147:1192-1203 April 18, 2023Vol 147, Issue 16 Advertisement Article InformationMetrics © 2023 American Heart Association, Inc.https://doi.org/10.1161/CIRCULATIONAHA.123.064041PMID: 37068134 Originally publishedApril 17, 2023 KeywordsEditorialsPDF download Advertisement SubjectsLipids and CholesterolRisk Factors