HMOX1型
血红素加氧酶
血红素
癌症研究
癌变
结直肠癌
血管生成
氧化应激
胆绿素
细胞保护
发病机制
转移
生物
癌症
免疫学
酶
生物化学
遗传学
作者
Rachitha Singhabahu,Sujani Madhurika Kodagoda Gamage,Vinod Gopalan
标识
DOI:10.1016/j.cpt.2023.04.001
摘要
The significance of the heme-metabolizing enzyme heme oxygenase-1 (HMOX1) in the pathogenesis of colorectal cancer (CRC) has not been fully explored. HMOX1 cytoprotection is imperative to limit oxidative stress. However, its roles in preventing carcinogenesis in response to high levels of heme are not thoroughly understood. This study reviews various mechanisms associated with the paradoxical role of HMOX1, which is advantageous for tumor growth, refractoriness, and survival of cancer cells amid oxidative stress in heme-induced CRC. The alternate role of HMOX1 promotes cell proliferation and metastasis through immune modulation and angiogenesis. Inhibiting HMOX1 has been found to reverse tumor promotion. Thus, HMOX1 acts as a conditional tumor promoter in CRC pathogenesis.
科研通智能强力驱动
Strongly Powered by AbleSci AI