Peripheral T Cell Subpopulations as a Potential Surrogate Biomarker during Atezolizumab plus Bevacizumab Treatment for Hepatocellular Carcinoma

医学 阿替唑单抗 肿瘤科 内科学 肝细胞癌 生物标志物 CD8型 外周血单个核细胞 贝伐单抗 T细胞 流式细胞术 免疫疗法 外围设备 临床试验 免疫系统 胃肠病学 癌症 免疫学 无容量 化疗 生物化学 体外 化学
作者
Yuki Shirane,Yasutoshi Fujii,Atsushi Ono,Hikaru Nakahara,C. Nelson Hayes,Ryo Miura,Serami Murakami,Naoya Sakamoto,Shinsuke Uchikawa,Hatsue Fujino,Takashi Nakahara,Eisuke Murakami,Masami Yamauchi,Daiki Miki,Tomokazu Kawaoka,Koji Arihiro,Masataka Tsuge,Shiro Oka
出处
期刊:Cancers [MDPI AG]
卷期号:16 (7): 1328-1328
标识
DOI:10.3390/cancers16071328
摘要

The therapeutic benefits of the immunotherapeutic combination of atezolizumab and bevacizumab (Atez/Bev) in hepatocellular carcinoma (HCC) vary. Therapeutic biomarkers might help improve outcomes for HCC patients receiving Atez/Bev therapy. The role of systemic immune profiles in HCC progression also remains unclear. This study aimed to evaluate the status and dynamics of peripheral T cell subpopulations in HCC patients receiving Atez/Bev treatment and to explore biomarkers predictive of a therapeutic response. We enrolled 83 unresectable advanced HCC patients who commenced Atez/Bev treatment at our hospital between October 2020 and June 2022. Peripheral T cell subpopulations in peripheral blood mononuclear cells at baseline and 3 weeks post-treatment were investigated using flow cytometry and compared with those in control samples from 18 healthy individuals. We retrospectively analyzed the association between peripheral T cell subpopulation profiles and clinical outcomes. Baseline peripheral T cell subpopulations could be profiled in 70 patients with sufficient cell counts, among whom 3-week subpopulations could be evaluated in 51 patients. Multivariate analysis showed that a high baseline proportion of CD8+ central memory T (TCM) cells was independently associated with longer progression-free survival (PFS). Further, overall survival (OS) was significantly prolonged in patients with increased CD8+ effector memory T (TEM) cell proportions. In conclusion, TCM proportion at baseline might be a good indicator of the efficacy of Atez/Bev therapy. Furthermore, observation of increasing TEM proportions might be an early predictor of the potential clinical benefits of treatment.

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