Incremental Value of Stroke-Induced Structural Disconnection in Predicting Global Cognitive Impairment After Stroke

断开 医学 冲程(发动机) 逻辑回归 神经影像学 优势比 内科学 认知 物理医学与康复 精神科 政治学 机械工程 工程类 法学
作者
Chensheng Pan,Guohua Chen,Ping Jing,Guo Li,Yuanhao Li,Jinfeng Miao,Wenzhe Sun,Yanyan Wang,Yan Lan,Xiuli Qiu,Xin Zhao,Jie Mei,Shanshan Huang,Lifei Lian,Zhou Zhu,Suiqiang Zhu
出处
期刊:Stroke [Ovid Technologies (Wolters Kluwer)]
卷期号:54 (5): 1257-1267 被引量:1
标识
DOI:10.1161/strokeaha.122.042127
摘要

Poststroke cognitive impairment (PSCI) is highly prevalent in stroke survivors and correlated with unfavorable clinical outcomes. This study aimed to identify the neural substrate of PSCI using atlas-based disconnectome analysis and assess the value of disconnection score, a baseline measure for stroke-induced structural disconnection, in PSCI prediction.A multicenter prospective cohort of 676 first-ever patients with acute ischemic stroke was enrolled from 3 independent hospitals in China. Sociodemographic, clinical, and neuroimaging data were collected at acute stage of stroke. Cognitive assessment was performed at 3 months after stroke. Voxel-wise and tract-wise disconnectome analysis were performed to uncover the strategic structural disconnection pattern for global PSCI. Disconnection score was calculated for each participant in leave-one-dataset-out cross-validation. Multivariable logistic regression was performed for the association between disconnection score and PSCI. Prediction models with and without disconnection score were developed, cross-validated, and compared in terms of discrimination and goodness-of-fit.Compared with lesions of non-PSCI, those of PSCI were more likely to have fiber connections with left prefrontal cortex and left deep structures (thalamus and basal ganglia). Disconnection score could predict the risk and severity of PSCI during cross-validation, and was independently associated with PSCI after controlling for all baseline covariates (odds ratio, 1.38 [95% CI, 1.17-1.64]; P<0.001). Incorporating disconnection score into a reference model with 6 known predictors resulted in significant improvement in both discrimination and goodness-of-fit throughout cross-validation.A strategic structural disconnection pattern centered on left prefrontal cortex, thalamus, and basal ganglia is identified for global PSCI using indirect disconnectome analysis. The baseline disconnection score is independently predictive of PSCI and has significant incremental value to preexisting sociodemographic, clinical, and neuroimaging predictors.URL: http://www.chictr.org.cn/enIndex.aspx; Unique identifier: ChiCTR-ROC-17013993.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
万能图书馆应助YYYY采纳,获得10
刚刚
hhf完成签到,获得积分10
刚刚
淡然尔蝶完成签到,获得积分10
刚刚
1秒前
liuliu发布了新的文献求助10
1秒前
米夏完成签到 ,获得积分10
1秒前
淡然水绿完成签到,获得积分10
1秒前
Sylvia_J完成签到 ,获得积分10
1秒前
sherrycofe应助dororo采纳,获得10
2秒前
2秒前
录录完成签到,获得积分10
3秒前
JJJJJJJJJJJ发布了新的文献求助10
3秒前
Binkolo完成签到,获得积分10
3秒前
科目三应助Lucas采纳,获得10
4秒前
大贝发布了新的文献求助10
4秒前
superhanlei完成签到 ,获得积分10
4秒前
蛋白激酶发布了新的文献求助10
5秒前
尼克11完成签到,获得积分10
5秒前
开心的破茧完成签到,获得积分10
5秒前
chriselva应助易槐采纳,获得20
5秒前
二七完成签到,获得积分10
5秒前
大方笑阳完成签到,获得积分10
6秒前
小杨爱吃羊完成签到 ,获得积分10
6秒前
6秒前
7秒前
序与海完成签到,获得积分10
8秒前
yu发布了新的文献求助20
8秒前
拓跋涵易发布了新的文献求助10
8秒前
小臭屁完成签到,获得积分10
9秒前
小田完成签到 ,获得积分10
9秒前
sqrt138应助jucy采纳,获得10
9秒前
10秒前
传奇3应助ECHO采纳,获得10
10秒前
11秒前
丁一完成签到,获得积分10
11秒前
小杨完成签到 ,获得积分10
12秒前
麻辣烫发布了新的文献求助10
12秒前
Luisa完成签到,获得积分10
12秒前
abc完成签到,获得积分10
13秒前
斯文败类应助俭朴的世立采纳,获得10
13秒前
高分求助中
Sustainability in Tides Chemistry 2800
The Young builders of New china : the visit of the delegation of the WFDY to the Chinese People's Republic 1000
Rechtsphilosophie 1000
Bayesian Models of Cognition:Reverse Engineering the Mind 888
Le dégorgement réflexe des Acridiens 800
Defense against predation 800
A Dissection Guide & Atlas to the Rabbit 600
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3134421
求助须知:如何正确求助?哪些是违规求助? 2785363
关于积分的说明 7771655
捐赠科研通 2440968
什么是DOI,文献DOI怎么找? 1297647
科研通“疑难数据库(出版商)”最低求助积分说明 625023
版权声明 600812